Antisense Oligonucleotide: Basic Concept and its Therapeutic Application
نویسندگان
چکیده
Antisense oligonucleotides are synthetic genetic materials that interact with natural genetic material and modulate them in a systematic way. Antisense oligonucleotides as a form of molecular medicine to modulate gene function was first acknowledged in the late 1970s. This therapy involves blocking translation, thereby inhibiting protein formation. Recently, antisense technology has been resurrected and has generated considerable enthusiasm in the research. Antisense oligonucleotides have proven to be valuable in gene functionalization and target validation and also represent a novel therapeutic strategy for wide range of diseases such as genetic disorders, cancers, and infectious diseases. Thus, in the present review an attempt is made to help the apprentice understand the basic concept of the antisense technology and its therapeutic applications.
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